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Accurately targeting DUBs to induce nonapoptotic PCD within tumor cells is also a major concern since the simultaneous nonselective induction of ferroptosis in cancer cells and immune cells causes immunosuppression 96 , 169 , 170
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Although this procedure does not involve systemic chemotherapy, it can increase the risk for HBV reactivation, particularly for HBsAg-positive individuals.[34] Assessing Risk for HBV Reactivation When assessing the risk of HBV reactivation, it is important to consider both virologic factors and immunosuppressive factors, specifically hepatitis B serologic status and type of immunosuppression